A handheld weapon built by the Breen Confederacy, designed to be effective against moving vessels or surface emplacements. Although somewhat bulky, the weapon is surprisingly light and powerful for its size. The Breen guarantee it will cut through reactive armour in the range of six to fifteen centimetres, and shields to a capacity of 4.6 Gigajoules. It fires in pulses, and the rapid recharge makes it a popular item on the export market. Thousands of these weapons have been sold by the Breen, making their way into the hands of various arms dealers.

In 2373, Quark and Gaila sold a CRM-144 to a Pythagos pirate.